Séamus Holden
Bacterial Biophysics Lab
My lab uses advanced light microscopy to study the biophysics of bacterial growth and division. We study how proteins function as nanoscale machines that build complex microscale structures. We particularly focus on proteins that build and remodel the bacterial cell wall, which is one of the most important targets for antibiotics. To achieve this we use super-resolution microscopy to follow the activity of individual cell wall synthesis proteins at nanoscale resolution inside live bacteria.